Table 3.
Suboptimal anti-CD154-based immunosuppression
| Monkey no. (IEQ/kg) |
Treatment | Survival (days) |
|---|---|---|
| 8 (11 500) | RPM (low), anti-CD154 (low)1 |
24 |
| 9 (12 500) | RPM and anti-CD154 | 65 |
| 10 (14 300 + 8200) | 160 | |
| 11 (15 700) | RPM, DST and anti-CD1542 (DST and RPM on day 03) |
14 |
| 12 (20 800) | RPM, DST and anti-CD154 (DST on day −17) |
96 |
| 13 (16 100) | RPM, DST and anti-CD154 (DST on day −2) |
100 |
1
Anti-CD154 treatment started at the time of transplantation.
2
When used with DST, the first dose of anti-CD154 was given at the time of the lymphocyte infusion and then continued at the time of transplantation.
3
Rapamycin was started on day 0, along with DST and anti-CD154. Rapamycin started on day −2 for all other monkeys.