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Optimized anti-CD154-based immunosuppression
| Monkey no. (IEQ/kg) |
Treatment | Survival (days) |
|---|---|---|
| 14 (17000) | RPM, DST and anti-CD154 | 130 |
| 15 (10800) | (DST on day −7 to −3) | 180 |
| 16 (7400) | 230 | |
| 17 (10200) | RPM, DST and anti-CD154 (DST on day -2; Repeat Rx1 day 100 and day 200) |
260 |
Repeat Rx consisted of rapamycin at 1 mg/kg p.o. qd and anti-CD154 20 mg/kg i.v. 2×/week for a two-week period starting on day 100 and 200.
