Skip to main content
PMC home page
Applied Microbiology logoLink to Applied Microbiology
. 1969 Sep;18(3):406–409. doi: 10.1128/am.18.3.406-409.1969

Production of Luteoskyrin, a Hepatotoxic Pigment, by Penicillium islandicum Sopp

Yoshio Ueno 1, Ichijiro Ishikawa 1
PMCID: PMC377994  PMID: 5373676

Abstract

Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for preparation of 14C-labeled luteoskyrin was 2-14C-malonate.

Full text

PDF
408

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. KITAGAWA I., SHIBATA S. Metabolic products of fungi. X. The structure of rubroskyrin and its relation to the structure of luteoskyrin. Pharm Bull. 1956 Aug;4(4):309–313. doi: 10.1248/cpb1953.4.309. [DOI] [PubMed] [Google Scholar]
  2. Ohba Y., Fromageot P. Interactions entre pigments et acides nucléiques. 4. Complexes spécifiques et non spécifiques entre la lutéoskyrine, les ions magnésium et les acides nucléiques. Eur J Biochem. 1967 Apr;1(2):147–151. doi: 10.1111/j.1432-1033.1967.tb00056.x. [DOI] [PubMed] [Google Scholar]
  3. UENO I., UENO Y., TATSUNO T., URAGUCHI K. MITOCHONDRIAL RESPIRATORY IMPAIRMENT BY LUTEOSKYRIN, A HEPATOTOXIC PIGMENT OF PENICILLIUM ISLANDICUM SOPP. Jpn J Exp Med. 1964 Jun;34:135–152. [PubMed] [Google Scholar]
  4. UENO Y., UENO I., TATSUNO T., URAGUCHI K. LES EFFETS DE LA LUT'EOSKYRINE, SUBSTANCE TOXIQUE DU PENICILLIUM ISLANDICUM SOPP, SUR LE GONFLEMENT DES MITOCHONDRIES. Jpn J Exp Med. 1964 Aug;34:197–209. [PubMed] [Google Scholar]
  5. UMEDA M. CYTOTOXIC EFFECTS OF THE MYCOTOXINS OF PENICILLIUM ISLANDICUM SOPP, LUTEOSKYRIN AND CHLORINE-CONTAINING PEPTIDE ON CHANG'S LIVER CELLS AND HELA CELLS. Acta Pathol Jpn. 1964 Aug;14:373–394. doi: 10.1111/j.1440-1827.1964.tb00681.x. [DOI] [PubMed] [Google Scholar]
  6. Ueno Y., Saheki M. Inhibitory effects of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, and chemically related pigments on a protozoon, Tetrahymena pyriformis GL. Jpn J Exp Med. 1968 Jun;38(3):157–164. [PubMed] [Google Scholar]
  7. Ueno Y., Ueno I., Ito K., Tatsuno T. Impairments of RNA synthesis in Ehrlich ascites tumour by luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp. Experientia. 1967 Dec 15;23(12):1001–1002. doi: 10.1007/BF02136409. [DOI] [PubMed] [Google Scholar]
  8. Ueno Y., Ueno I., Mizumoto K., Tatsuno T. The binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum sopp, to deoxyribonucleohistone. J Biochem. 1968 Mar;63(3):395–397. [PubMed] [Google Scholar]
  9. Ueno Y., Ueno I., Mizumoto K. The mode of binding of luteoskyrin, a hepatotoxic pigment of Penicillium islandicum Sopp, to deoxyribonucleic acid. Jpn J Exp Med. 1968 Feb;38(1):47–64. [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES