Table 1.
Comparison of percent changes in cardiac fibroblast functional parameters resulting from incubation with either 5 ng/ml of TNF-α or untreated cardiac inflammatory cells for 24 hours
| Fibroblast functional parameter | TNF-α (5 ng/mL) | Untreated inflammatory cells |
|---|---|---|
| Proliferation | +6% | +114%* |
| Collagen synthesis | +50%* | +277%* |
| Total MMP activity | +58%* | +110%* |
| MMP-2 activity | +145%* | +129%* |
| Collagen gel contraction area | −60%* | −84%* |
| β1 integrin protein | −46%* | −25%* |
Note:
*
P < 0.05.
Abbreviations: TNF-α, tumor necrosis factor alpha; MMP, matrix metalloproteinase.