Table 2.
Allelic and genotypic frequency
|
ESR1 | |||
|---|---|---|---|
| XbaI | MCIa (N=204) | AD (N=350) | CONTROLS (N=262) |
| Allele | |||
| X | 0.426 | 0.409 | 0.395 |
| x | 0.574 | 0.591 | 0.605 |
| Genotype | |||
| XX | 0.157 | 0.154 | 0.156 |
| Xx | 0.539 | 0.509 | 0.477 |
| xx | 0.304 | 0.337 | 0.366 |
| H-W* | |||
| p Value | 0.197 | 0.376 | 1.000 |
| PvuII | |||
| Allele | |||
| P | 0.488 | 0.480 | 0.462 |
| p | 0.512 | 0.520 | 0.538 |
| Genotype | |||
| PP | 0.225 | 0.209 | 0.214 |
| Pp | 0.525 | 0.543 | 0.496 |
| pp | 0.250 | 0.249 | 0.290 |
| H-W* | |||
| p Value | 0.575 | 0.110 | 1.000 |
| SNP1 | |||
| Allele | |||
| A | 0.191 | 0.189 | 0.174 |
| G | 0.809 | 0.811 | 0.826 |
| Genotype | |||
| AA | 0.039 | 0.037 | 0.030 |
| AG | 0.304 | 0.303 | 0.286 |
| GG | 0.657 | 0.660 | 0.684 |
| H-W* | |||
| p Value | 0.818 | 0.861 | 1.000 |
| ESR2 | |||
| SNP2 | |||
| Allele | |||
| A | 0.424 | 0.419 | 0.378 |
| G | 0.576 | 0.581 | 0.622 |
| Genotype | |||
| AA | 0.201 | 0.189 | 0.133 |
| AG | 0.446 | 0.460 | 0.489 |
| GG | 0.353 | 0.351 | 0.378 |
| H-W* | |||
| p Value | 0.245 | 0.325 | 0.591 |
| APOE | |||
| Allele | |||
| 2 | 0.027 | 0.034 | 0.057 |
| 3 | 0.743 | 0.665 | 0.842 |
| 4 | 0.230 | 0.301 | 0.101 |
| Genotype | |||
| 2,2 | 0.000 | 0.000 | 0.008 |
| 2,3 | 0.044 | 0.046 | 0.092 |
| 2,4 | 0.010 | 0.017 | 0.008 |
| 3,3 | 0.574 | 0.434 | 0.698 |
| 3,4 | 0.294 | 0.420 | 0.195 |
| 4,4 | 0.078 | 0.083 | 0.000 |
| H-W* | |||
| p Value | 0.217 | 0.814 | 0.102 |
| Genetic profile | |||
| XPAA(+) | 0.709 | 0.708 | 0.674 |
| XPAA(−) | 0.291 | 0.292 | 0.326 |
*Hardy-Weinberg probability test