Table 2.

Cytokine Array Analysis of Collagen X Null Verses Wild Type Trabecular Bone and Hypertrophic Chondrocyte Derived CoCulture Media With or Without Lineage Negative Cells

HSPG	Cytokines	TB	HC	TB+lin−	HC+lin−
	SCF	−		−
√	IL-7	−		−
√	SDF-1 α	−	+	−	−
	Flt-3L	+	+
	TSLP
√	IL-10	−
√	IL-12p70	−
√	IL-12p40	−			+
	IL-11	−
√	IL-6	−	+	−	−
√	IL-5	−		−
√	IL-4	−		−
√	IL-3	−		−
	IL-9	−		−
	IL-13
√	IL-2	+	+
√	G-CSF
√	VEGF	−		−
√	6Ckine	−
√	bFGF	−
	M-CSF	−	+	−
√	TARC	−		−
√	RANTES	−	+	−	−
√	MIP-2			−
	leptin			−
√	IL-1α	+	+
√	IL-1β	+	+
√	PF-4	+	+	+	+
√	CTACK	+
	pro-MMP9	+	+
√	IFN-γ			+	+
	IL-15			+
	BLC		+	+	+
	Resistin		+	+	+
√	MCP-1
√	GM-CSF				+
	LIX
	CXCL16		+		+
	IL-17		+
√	CRG-2

√ indicates cytokines that bind to HSPG. Cytokines are ordered from early, to late, to no reported involvement in B cell development.

SCF, stem cell factor; IL, interleukin; SDF-1, stromal derived factor-1; Flt-3L, FMS-like tyrosine kinase 3 ligand; TSLP, thymic stromal derived lymphopoietin; G-CSF, granulocyte colony stimulating factor; VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor; M-CSF, macrophage colony stimulating factor; TARC, thymus and activation regulated chemokine; MIP, macrophage inflammatory protein; PF, platelet factor; CTACK, cutaneous T cell attracting chemokine; MMP, matrix metaloproteinase; IFN, interferon; BLC, B lymphocyte chemoattractant; MCP, monocyte chemotactic protein; GM-CSF, granulocyte macrophage colony stimulating factor; LIX, lipopolysaccharide induced CXC chemokine; CRG-2, cytokine responsive gene 2; TB, trabecular bone, HC, hypertrophic chondrocytes; lin, lineage negative; −, decreased compared WT, +, increased compared to WT; HSPG, heparan sulfate proteoglycans.