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(A) Early in the course of lymphatic dysfunction, the accumulated, protein-rich interstitial fluid remains mobile and can be displaced by the examining finger (‘pitting edema’). (B) In chronic lymphedema, but not in the non-lymphatic forms of edema, structural changes in the tissues ultimately obliterate the ‘pitting’ quality of the edema. Here the examining finger can elicit no change in the external contour of the skin (dotted line).
