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. 2013 Sep 23;4:109. doi: 10.3389/fpsyt.2013.00109

Table 2.

Pharmacological inhibition of FAAH inhibition and properties of psychostimulants.

FAAH inhibitors Drug Animal Outcome Effects Reference
AM404 Cocaine Rat Drug-induced lowering of brain reward/self-stimulation threshold Impaired Vlachou et al. (252)
Drug-induced acute hyperlocomotion Attenuated Vlachou et al. (252)
URB597 Cocaine Monkey SA – effect of agonist after drug-taking extinction No effect Justinova et al. (260)
SA – drug-taking behavior No change Justinova et al. (260)
Rat Cocaine-induced increase in VTA DA activity Preserved Luchicchi et al. (259)
Cocaine-induced alterations in firing of NAc shell spiny neurons Attenuated Luchicchi et al. (259)
URB597, PMSF Cocaine Rat SA – drug-seeking responses/intake No change Adamczyk et al. (261)
SA – drug-induced reinstatement Attenuated Adamczyk et al. (261)
SA – cue-induced reinstatement Attenuated Adamczyk et al. (261)