Table 3.

Effects of CB1 cannabinoid receptor deletion and properties of psychostimulants; CB1 receptor antagonists and properties of psychostimulants.

Genotype	Drug	Animal	Outcome	Effects	Reference
CB1 KO	Cocaine	Mouse	Drug-induced acute hyperlocomotion	Preserved	Martin et al. (262), Houchi et al. (263), Miller et al. (264)
			Drug-induced acute hyperlocomotion	Attenuated	Corbille et al. (267), Li et al. (253)
			Drug-induced motor sensitization	Preserved	Martin et al. (262)
			Drug-induced motor sensitization	Attenuated	Corbille et al. (267)
			Drug-induced increase in NAc DA levels	Preserved	Soria et al. (255)
			Drug-induced increase in NAc DA levels	Attenuated	Li et al. (253)
			CPP – behavior acquisition under chronic unpredictable stress exposure	Preserved	Martin et al. (262), Houchi et al. (263), Miller et al. (264)
				Enhanced	Miller et al. (264)
			SA – behavior acquisition in restrained mobility protocol	Impaired	Soria et al. (255), Xi et al. (258)
				Preserved	Cossu et al. (275)
			SA – breaking point under PR schedule	Decreased	Soria et al. (255)
	Amphet.		Drug-induced acute hyperlocomotion	Preserved	Houchi et al. (263)
			Drug-induced acute hyperlocomotion	Attenuated	Corbille et al. (267)
			Drug-induced motor sensitization	Attenuated	Corbille et al. (267)
			SA – behavior acquisition in restrained mobility protocol	Preserved	Cossu et al. (275)
Antagonist	Drug	Animal	Outcome	Effects	Reference
AM251	Cocaine	Mouse	Drug-induced acute hyperlocomotion	Attenuated	Corbille et al. (267)
			Drug-induced motor sensitization (induction)	Attenuated	Corbille et al. (267)
			Drug-induced motor sensitization (expression)	Preserved	Corbille et al. (267)
			CPP – drug-induced reinstatement	Preserved	Vaughn et al. (276)
			CPP – stress-induced reinstatement	Impaired	Vaughn et al. (276)
		Rat	Drug-induced lowering of brain reward/self-stimulation threshold	Attenuated	Xi et al. (250)
			Drug-induced increase in NAc DA levels	Preserved	Xi et al. (257)
			Drug-induced increase in NAc glutamate	Attenuated	Xi et al. (257)
			SA – drug-induced reinstatement	Attenuated	Xi et al. (257), Adamczyk et al. (277)
			SA – cue-induced reinstatement	Attenuated	Adamczyk et al. (277)
			SA – drug-seeking responses/intake	No change	Xi et al. (250), Adamczyk et al. (277)
			SA – breaking point under PR schedule	Decreased	Xi et al. (250)
	METH	Rat	SA – drug-seeking responses/intake	Decreased	Vinklerova et al. (278)
SR141716A	Amphet., cocaine	Gerbils	Drug-induced acute hyperlocomotion	Decreased	Poncelet et al. (279)
			Reinstatement of drug-seeking	Decreased	Poncelet et al. (279)
	Cocaine	Monkey	SA – drug-seeking responses/intake	No change	Tanda et al. (280)
		Mouse	Drug-induced acute hyperlocomotion	Attenuated	Gerdeman et al. (268)
				Preserved	Lesscher et al. (266)
			Drug-induced motor sensitization (induction)	Attenuated	Gerdeman et al. (268)
				Preserved	Lesscher et al. (266)
			Drug-induced motor sensitization (expression)	Preserved	Gerdeman et al. (268)
			Drug-induced motor sensitization (maintenance – specific to a drug-paired environment)	Reversed	Gerdeman et al. (268)
			CPP – behavior acquisition	Impaired	Yu et al. (281)
			CPP – drug-induced reinstatement	Impaired	Yu et al. (281)
			SA – behavior acquisition	Preserved	Lesscher et al. (266)
			SA – “extinction burst responding”	Attenuated	Ward et al. (282)
			SA – time for behavior extinction	Decreased	Ward et al. (282)
			SA – cue-induced reinstatement	Attenuated	Ward et al. (282)
			SA – drug-seeking responses/intake	No change	De Vries et al. (283), Lesscher et al. (266)
			SA – breaking point under PR schedule	Decreased	Soria et al. (255)
		Rat	Drug-induced acute hyperlocomotion	Preserved	Chaperon et al. (265)
				Attenuated	Cheer et al. (254)
			Drug-induced motor sensitization (expression)	Attenuated	Filip et al. (269)
			Drug-induced lowering of brain reward/self-stimulation threshold	Preserved	Vlachou et al. (251), Xi et al. (250)
			Drug-induced decrease in VP GABA efflux	Preserved	Caille and Parsons (256)
			Drug-induced increase in NAc DA levels	Preserved	Caille and Parsons (256)
				Suppressed	Cheer et al. (254)
			Drug discrimination	Preserved	Filip et al. (269)
			SA – drug-seeking responses/intake	No change	De Vries et al. (283), Caille and Parsons (256), Filip et al. (269), Xi et al. (250)
			SA – breaking point under PR schedule	No change	Xi et al. (250)
				Decreased	Orio et al. (284)
			SA – drug-induced reinstatement	Attenuated	De Vries et al. (283), Filip et al. (269)
			SA – HU210-induced reinstatement	Attenuated	De Vries et al. (283)
			SA – cue-induced reinstatement	Attenuated	De Vries et al. (283), Filip et al. (269)
			SA – stress-induced reinstatement	Preserved	De Vries et al. (283)
			CPP – behavior acquisition	Impaired	Chaperon et al. (265)
			CPP – behavior expression	Preserved	Chaperon et al. (265)
	MDMA	Mouse	CPP – drug-induced reinstatement	Increased	Daza-Losada et al. (285)
			CPP – behavior acquisition	Impaired	Rodriguez-Arias et al. (286)
		Rat	CPP – behavior acquisition	Impaired	Braida et al. (287)
			SA – drug-seeking responses/intake	Increased	Braida and Sala (288)
	METH	Mouse	CPP – behavior acquisition	Impaired	Yu et al. (281)
			CPP – drug-induced reinstatement	Impaired	Yu et al. (281)
		Rat	Drug-induced reinstatement of drug-seeking behavior	Attenuated	Anggadiredja et al. (289)
			Cue-induced reinstatement of drug-seeking behavior	Attenuated	Anggadiredja et al. (289)