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. Author manuscript; available in PMC: 2013 Sep 23.
Published in final edited form as: J Neurochem. 2012 Nov 21;124(1):59–68. doi: 10.1111/jnc.12059

Fig. 2.

Fig. 2

Effect of SC-560 treatment on astrocyte activation. (a) Representative immunostaining of astrocytes in the hippocampal subiculum of 3 × Tg-AD mice treated with vehicle (left) or SC-560 (right). Double-staining of glial fibrillary acidic protein (GFAP) and amyloid deposits (Congo red) showing reactive astrocyte surrounding amyloid plaques. Scale bar, 100 μm. (b) Representative western blot of GFAP in the brain homogenates of 3 × Tg-AD mice treated with vehicle or SC-560. β-actin was used as loading control. (c) Quantification of GFAP expression. Data shown are the means ± SEM (n = 6 mice per group).