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. Author manuscript; available in PMC: 2013 Sep 23.
Published in final edited form as: J Neurochem. 2012 Nov 21;124(1):59–68. doi: 10.1111/jnc.12059

Fig. 4.

Fig. 4

SC-560 treatment reduces phosphorylated tau. (a) Representative images of AT8 staining (a) in hippocampal subiculum in 3 × Tg-AD mice treated with vehicleorSC-560. Scale bar, 100 μm. Boxed regions (left) indicate the areas magnified (right), respectively. (b) Quantification of AT8-positive cells in the subiculum. Data are means ± SEM (n = 6 per group). *p < 0.05 versus vehicle-treated 3 × Tg-AD mice. (c) Representative western blot of phosphorylated tau (AT8) and total tau (TAU-5) in the brain homogenates of 3 × Tg-AD mice treated with vehicle or SC-560. β-actin was used as loading control. (d) Quantification of AT8 and TAU-5 expression. Data shown are the means ± SEM (n = 6 mice per group). *p < 0.05 versus vehicle-treated 3 × Tg-AD mice.