Table 3. Risk of Having a Child With Moderate Language Delay According to Use of Maternal Folic Acid Supplements.
| Supplement Use (4 wk Before to 8 wk After Conception) | No. (%) of Children | Odds Ratio (95% CI) | ||
|---|---|---|---|---|
| Overall (n = 38 750)a | With Moderate Language Delay | Unadjusted (n = 38750)a | Adjusted (n = 36136)b | |
| None | 9379 (24.2) | 408 (4.4) | 1 [Reference] | 1 [Reference] |
| Other supplements, no folic acid | 2564 (6.6) | 106 (4.1) | 0.94 (0.76-1.18) | 1.04 (0.83-1.30) |
| Folic acid only | 7326 (18.9) | 227 (3.1) | 0.70 (0.59-0.82) | 0.82 (0.69-0.97) |
| Folic acid plus other supplements | 19 481 (50.3) | 549 (2.8) | 0.63 (0.56-0.72) | 0.79 (0.68-0.90) |
a
Excluding severe language delay (n=204).
b
Adjusted for maternal education, maternal body mass index, parity, and marital status. Severe language delay (n=204) and missing confounder data (n=2614) excluded from analysis.