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. Author manuscript; available in PMC: 2014 Jun 27.
Published in final edited form as: Cell Rep. 2013 May 30;3(6):1910–1920. doi: 10.1016/j.celrep.2013.04.028

Figure 6. Proposed Models of Actin Filament Nucleation and Polymerization Mediated by Tandem W Domains.

Figure 6

(A–C) Proposed model of Cobl-mediated actin nucleation. The actin-Cobl nucleus allows the pointed-end but not the barbed-end growth (A). Slow growth at the pointed end triggers ATP hydrolysis in actin(Wb). The bound Cobl-Wb is expulsed from actin(Wb), and the steric hinderance imposed by actin(Wa) is released (B). Rapid growth of actin filament proceeds at the barbed end, and slow depolymerization at the pointed end eventually releases the bound Cobl into solution (C).

(D) Proposed nucleus of actin-JMY.