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Antagonism by metaflumizone (10 µM) of the use-dependent inhibition of rat Nav1.4 sodium channels expressed in Xenopus oocytes by lidocaine (200 µM). Left inset: pulse protocol used. Right inset: Boltzmann plots of the voltage dependence of activation and fast inactivation of rat Nav1.4 sodium channels; dashed line indicates the prepulse potential (−50 mV) used to induce fast inactivation without channel activation. The figure is re-drawn from the data of von Stein and Soderlund [21].
