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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Pestic Biochem Physiol. 2013 Mar 21;106(3):101–112. doi: 10.1016/j.pestbp.2013.03.004

Fig. 7.

Fig. 7

Helical wheel representation of the amino acid sequences of the four S6 transmembrane domains arranged in relation to the central ion pore as proposed by Mike and Lukacs [23]. Residues shown by site-directed mutagenesis are shown in boldface; The Phe1579 residue thought to be a critical determinant of binding for all SCI drugs is boxed.