Table 1.

Grade 2 to 4 Toxicities

Toxicity	Acute (n=64),a Grade			Late (n=60),b Grade			1 Year (n=59),c Grade			2 Years (n=58),c Grade			3 Years (n=47),c Grade			4 Years (n=37),c Grade			5 Years (n=34),c Grade
	2	3	4	2	3	4	2	3	4	2	3	4	2	3	4	2	3	4	2	3	4
Hematologic	3 (4.7%)	9(14.1%)	50(78.1%)	3 (5.0%)	1 (1.7%)	8 (13.3%)	2 (3.4%)	1 (1.7%)	7 (11.9%)	1 (1.7%)	0	2 (3.4%)	0	0	0	0	0	0	0	0	0
Infection	9(14.1%)	14(21.9%)	3 (4.7%)	4 (6.7%)	3 (5.0%)	1 (1.7%)	4 (6.8%)	3(5.1%)	1 (1.7%)	1 (1.7%)	0	0	0	0	0	0	0	0	0	1 (2.9%)	0
Skin	22 (34.4%)	18(28.1%)	3 (4.7%)	2 (3.3%)	2 (3.3%)	0	1 (1.7%)	2 (3.4%)	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0
Mucous membrane	9(14.1%)	1 (1.6%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Subcutaneous tissue	0	0	1 (1.6%)	1 (1.7%)	1 (1.7%)	1 (1.7%)	1 (1.7%)	1 (1.7%)	1 (1.7%)	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0
Hepatic	4 (6.3%)	0	0	1 (1.7%)	0	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Diarrhea	8(12.5%)	3 (4.7%)	0	1 (1.7%)	0	0	0	0	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0
Nausea/vomiting	29 (45.3%)	5 (7.8%)	2 (3.1%)	2 (3.3%)	0	0	2 (3.4%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Other gastrointestinal	5 (7.8%)	3 (4.7%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Neurological	5 (7.8%)	2 (3.1%)	0	2 (3.3%)	0	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Pain	9(14.1%)	1 (1.6%)	1 (1.6%)	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1 (2.9%)	0	0
Genitourinary	3 (4.7%)	1 (1.6%)	0	2 (3.3%)	0	0	1 (1.7%)	0	0	0	0	0	0	0	0	1 (2.7%)	0	0	0	0	0
Respiratory	2 (3.1%)	0	1 (1.6%)	1 (1.7%)	0	1 (1.7%)	1 (1.7%)	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0	0
Cardiac	0	0	1 (1.6%)	1 (1.7%)	1 (1.7%)	0	1 (1.7%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Fever	8(12.5%)	1 (1.6%)	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Joint	1 (1.6%)	0	0	3 (5.0%)	1 (1.7%)	0	2 (3.4%)	0	0	1 (1.7%)	0	0	1 (2.1%)	0	0	0	1 (2.7%)	0	0	0	0
Peripheral nerves	1 (1.6%)	0	0	1 (1.7%)	2 (3.3%)	0	1 (1.7%)	1 (1.7%)	0	0	1 (1.7%)	0	0	1 (2.1%)	0	0	0	0	0	0	0
Vascular	1 (1.6%)	2 (3.1%)	0	2 (3.3%)	1 (1.7%)	0	1 (1.7%)	1 (1.7%)	0	0	0	0	1 (2.1%)	0	0	0	0	0	0	0	0
Other	20 (31.3%)	6 (9.4%)	3 (4.7%)	5 (8.3%)	0	2 (3.3%)	5 (8.5%)	0	0	0	0	1 (1.7%)	0	0	1 (2.1%)	0	0	0	2 (5.9%)	0	0

^aThe acute period is ≤6 months from the initiation of radiotherapy.

^bThe late period is >6 months from initiation of radiotherapy.

^cThe yearly rates are measured from the initiation of radiotherapy using intervals of ±6 months