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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Int J Antimicrob Agents. 2013 Jun 24;42(3):232–237. doi: 10.1016/j.ijantimicag.2013.04.027

Table 4.

Comparison of type of fluoroquinolone (FQ) exposure to mutations in gyrAa

Older FQs onlyb,c (N = 9) [n (%)] Newer FQs onlyb,c (N = 25) [n (%)] P-value
gyrA codon 94 1 (11) 9 (36) 0.16
gyrA codons 90, 91, 94 1 (11) 11 (44) 0.08
QRDR gyrA 3 (33) 12 (48) 0.45
gyrA 8 (89) 24 (96) 0.44

QRDR, quinolone resistance-determining region (extends from codons 74 to 113 in gyrA).

a

Mutations listed regardless of FQ susceptibility. Note that all mutations at codons 90, 91 or 94 occurred in FQ-resistant isolates.

b

Newer FQs include moxifloxacin, levofloxacin and gatifloxacin; older FQs include ofloxacin and ciprofloxacin.

c

Number of isolates with at least one mutation from designated location.