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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Mol Cell. 2012 Nov 21;49(2):359–367. doi: 10.1016/j.molcel.2012.10.016

Figure 3. Genetic effects on methylomic aging.

Figure 3

(A) We surveyed genomic variants for an association with age-associated methylation markers. 8 genetic variants, corresponding to 14 meQTLs, were chosen for validation. Of these, 7 were significant in the validation cohort and two showed an association with AMAR. (B) A plot of the trend between the methylation marker cg27367526 (STEAP2) and age. The state of variant rs42663 (GTPBP10) causes an offset in this relationship. (C) A second example for cg18404041 and rs2230534 (ITIH1, NEK4). A table of confirmed genetic associations is provided as Table S4.