Figure 1.

YZ-185 blocks the development of place preference to cocaine, but it does not produce CPP, place aversion, or alter the expression of cocaine's conditioned-rewarding effects. Data represent mean (±SEM) conditioning scores. Panel (a) depicts the lack of intrinsic efficacy of YZ-185 to produce CPP. Panel (b) depicts the effect of YZ-185 on the development of cocaine CPP in mice that received YZ-185 15 minutes prior to cocaine during conditioning sessions. The asterisk indicates a significant difference from the group that received saline (0 μmol/kg YZ-185). Panel (c) represents the effect of YZ-185 on the expression of cocaine place preference in mice that received YZ-185 only on after test.