Figure 7.

Tamalin deficiency blocks LTP formation after ECS. Three 100 Hz, 1-s-long stimuli trains, induced an immediate posttetanic potentiation lasting a few minutes then a long-term potentiation lasting several hours (LTP). a, Time course of fEPSPs evoked in the molecular layer of the DG by stimulating the medial perforant path. Slope at baseline (−10 to 0 min) and after induction of LTP (0 time mark). Points are average of traces from four WT and four TKO with and without ECS. For animals without ECS, no differences are evident in TKO with respect to WT mice. ECS blunted the LTP formation in TKO but did not alter posttetanic potentiation. Note that ECS administered 5 h before LTP recording blunted the response in WT but the reduction in LTP was much more pronounced in the TKO mice. b, fEPSP recorded in DG. Traces from top to bottom identify baseline fEPSP before LTP induction, 1 min after induction, and 1 h after induction. c, Input–output curve obtained before LTP induction in TKO and WT mice that underwent ECS.