Table 1.

Predicted physico-chemical properties of chemical compounds with inhibitory effects on 5-Lox

Compound	Molecular weighta	Solubility in pure water (μg/ml)a	Partition coefficient Log Pa	Permeability coefficient Kp (cm/h)b	Flux (Jmax) (μg/cm2/h)b	IC50 (5-Lox) (μM)c	Theoretical activity index (Jmax/IC50)
Zileuton	236.29	10	3.74	3.27×10−2	0.33	0.5	0.65
ABT-761	318.37	62	4.56	3.94×10−2	2.44	0.023	106.09
Licofelone	379.88	1.82	6.73	5.77×10−1	1.05	0.23	4.57
Curcumin	368.38	50	2.92	1.34×10−3	0.07	8	0.0084
Garcinol	602.80	85	11.57	6.88×101	5,860	1.9	3,084.21

^aValues provided by the ACD software.

^bValues calculated using the Potts and Guy equation: Log k_p (cm/h)= −2.7+ 0.71 × log P− 0.0061 × MW and J_max = k_p × solubility

^cIC₅₀ values are estimates based on in vitro assays: Zileuton (37), ABT-761 (18), Licofelone (19), Curcumin (38) and Garcinol (22).