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. Author manuscript; available in PMC: 2013 Sep 23.
Published in final edited form as: Phys Life Rev. 2012 May 18;9(2):125–158. doi: 10.1016/j.plrev.2012.05.010

Fig. 13. Probing intermolecular reactions in solution using nanopores.

Fig. 13

(a) Scatter plots for 100 nM BSA only (black) and 100 nM BSA plus 270 nM anti-BSA-Fab (red) for a 17 nm conical pore at 1 V applied bias [71]. (b) Probing reaction between the PBCV-1 virus and an antibody specific to it using a sub-micrometer pore in glass [72]. (c) Use of lipid-coated solid-state nanopores for sensing in real time the evolution of amyloid-beta (Aβ) peptides. The lipids serve an important function in preventing clogging of the pores during transport of the peptides through the pore [73]. (d) Detection of small-molecule binding to DNA. SYBR Green II (SGII) is a dye that binds to random ssDNA sequences but not to poly(dA) [74]. Images obtained with permissions from the publishers. (For interpretation of the references to color in this figure, the reader is referred to the web version of this article.)