TABLE 2.

Inflammatory mediators that have been associated with early- and late-stage acne lesions

INFLAMMATORY MEDIATOR	FOUND IN ACNE LESIONS
	EARLY-STAGE ACNE LESIONS	LATE-STAGE ACNE LESIONS
Propionibacterium acnes	✓	✓
Cytokines	✓	✓
Defensins	✓	✓
Peptidases	✓
Neuropeptides	✓
Immunocompetent cells	✓	✓