Fig. 2.

Conserved Loz1 domains. (A) A schematic diagram of the Loz1 protein from S. pombe and S. japonicus. To identify conserved domains, the amino acid sequence of Loz1 was aligned with the Loz1 ortholog from S. japonicus by using CLUSTAL W. Black numbered boxes indicate the positions of the double zinc finger domains. The sequence alignment of other conserved domains has been shown and their positions indicated by striped rectangles on the schematic diagram. (B) An alignment of the Loz1 zinc finger domain with the corresponding region of Loz1 orthologs from S. japonicus, Penicillium marneffei, Aspergillus oryzae, Neurospora crassa, Mycosphaerella graminicola, and Cryptococcus neoformans. The cysteine and histidine residues that are predicted to coordinate zinc are shown in bold. The arginine altered to a glycine in loz1-1 is shown in bold and italics.