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Model systems for structure–function studies of cardiac LTCCs. (A, Upper) Adult rat ventricular cardiomyocyte. (A, Bottom) Differential LTCC targeting to distinct subcellular microdomains in cardiomyocytes. (B) Model systems for LTCC structure–function studies. (Scale bar, 20 μm.) (C) Topology of LTCC pore-forming α1C and auxiliary proteins (β, α2δ, and calmodulin).
