Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
ML-193 has no off-target effects at LTCCs, IP3Rs, RyRs, or TPCs. A, representative Ca2+ responses of ventricular myocytes to KCl (50 mm, a depolarizing agent), angiotensin II (Ang II, 100 nm, activates IP3 production), and isoproterenol (Iso, 100 nm, activates formation of second messengers cyclic ADP-ribose and NAADP) in the absence and presence of ML-193 (30 μm). B, comparison of the [Ca2+]i increases in response to the mentioned compounds in the absence and presence of ML-193.
