Table 2.

Incident Ischemic stroke, hazard ratio

	Unadjusted	Model 1 (adjusted for age, sex, income and education)	Model 2 (Model 1 + behavioral risk factors*)	Model 3 (Model 1 + biological risk factors†)	Model 4 (Model 1 + behavioral* + biological risk factors†)
Writes (n=3834)	Hazard Ratio (95% CI)	Hazard Ratio (95% CI)	Hazard Ratio (95% CI)	Hazard Ratio (95% CI)	Hazard Ratio (95% CI)
Neighborhood SES
Q1 (Highest), ref., N=968	1.00	1.00	1.00	1.00	1.00
Q2, N=960	1.33 (1.04–1.71)§	1.27 (0.98–1.63)	1.27 (0.98–1.64)	1.20 (0.93–1.56)	1.21 (0.93–1.56)
Q3, N=962	1.42 (1.11–1.83)§	1.27 (0.92–1.65)	1.26 (0.97–1.64)	1.17 (0.90–1.52)	1.17 (0.90–1.52)
Q4 (Lowest), N=944	1.56 (1.22–2.00)§	1.32 (1.01–1.72)§	1.30 (0.99–1.70)	1.16 (0.88–1.52)	1.15 (0.88–1.51)
Test of trend	P=0.0004	P=0.069	P=0.09	P=0.42	P=0.44
African Americans (n=785)‡
Neighborhood SES
Q1 (Highest) ref., N=197	1.00	1.00	1.00	1.00	1.00
Q2, N=205	0.74 (0.43–1.25)	0.68 (0.39–1.16)	0.66 (0.39–1.14)	0.70 (0.40–1.23)	0.68 (0.39–1.20)
Q3, N=208	0.84 (0.51–1.40)	0.70 (0.41–1.17)	0.63 (0.37–1.07)	0.72 (0.42–1.24)	0.64 (0.37–1.12)
Q4 (Lowest), N=175	0.71 (0.41–1.25)	0.60 (0.33–1.07)	0.59 (0.33–1.08)	0.67 (0.37–1.22)	0.67 (0.36–1.23)
Test of trend∥	P=0.30	P=0.08	P=0.05	P=0.17	P=0.13

^*Behavioral Risk Factors: smoking, alcohol use, and physical activity.

^†Biologic Risk Factors: EKG abnormalities, subclinical cardiovascular disease, hypertension, diabetes, Total/HD-cholesterol.

^‡Atrial fibrillation was not included as a biologic risk factor in the African American.

^§P<0.05 in comparison to Q1.

^∥Test of model fit for nested models compared to full model (Model 4)