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Induction of ligand or Siglec expression by pathogens can regulate inhibitory signaling
A. Activation of a TLR by a PAMP results in the generation of a Siglec ligand by regulating an enzyme or enzymes that regulate ligand availability. The generation of a Siglec ligand results in inhibitory signaling being brought into play
B. Activation of a TLR by a PAMP results in the induction of Siglec expression. This results in inhibitory signaling being brought into play.
