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. 2013 Sep 23;8(9):e75302. doi: 10.1371/journal.pone.0075302

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Overall levels of immunoglobulin (A = IgG, B = IgM, C = IgA) were measured in macaques (n = 30) at two time points – week 0 (prior to-vaccination and SIV challenge) and week 64 (after vaccination and SIV challenge). Dashed lines indicate the median values for each time point. P-values for comparison of the two time points were calculated with the Mann-Whitney test. Additionally, histograms show the fold changes in overall immunoglobulin (D = IgG, E = IgM, F = IgA) occurring after vaccination and SIV challenge.