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. 2013 Sep 23;8(9):e76498. doi: 10.1371/journal.pone.0076498

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© 2013 Mirzoyan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A, B) Ara/Caup expression is strongly reduced at the dorsal edge of the mesoderm (arrows) in tup ^isl-1 mutants. (C) Doc mutants (Df(3L)DocA) show a dramatic loss of Ara/Caup expression in the dorsal mesoderm (arrows). (D) In pnr ^VX6 mutants, Ara/Caup expression is severely reduced (arrows), but some Ara/Caup-positive cells remain in a striped pattern along the dorsal side of the embryo (asterisks). (E, F) A double immunostaining for Ara/Caup and Dmef2 reveals the absence of Ara/Caup in tin mutants (arrows). (G-J) Mirr-expressing cells are mildly reduced in tup ^isl-1 mutants (arrows in H) whereas a strong reduction of Mirr-positive cells is observed in Doc mutants (Df(3L)DocA) (arrows in I) and in pnr ^VX6 mutants (arrows in J). (K, L) tin mutants show a strong reduction of Mirr-expressing cells in the dorsal mesoderm (arrows in L). (M) Quantification of the phenotypes. The bar graph shows the percentage of embryos that were characterized by a reduction either of Ara/Caup or Mirr. Lateral views of stage 10/11 embryos are shown.