Figure 4. Virus recovery in organ samples from macaques administered immunosuppressive agents.
Each macaque was inoculated with saline (Y1-Y3, N1-N3) or immunosuppressive agents (Y4-Y6, N4-N6) as described in the legend for Figure 3. Macaques were inoculated with YOK91 (A, Y1-Y6) or NRT1 (B, N1-N6) on day 0. Tissue samples were collected at autopsy 7 days after virus inoculation. Tissue homogenates were prepared as 10% w/v solution. Virus titers under the detection limit (< 1.67TCID50/g tissue) are indicated as 0. R: right, L: left, RU: right upper lobe, RM: right middle lobe, RL: right lower lobe, LU: left upper lobe, LM: left middle lobe, LL: left lower lobe, LN chest: lymph nodes in the mediastinum.