Table 4. Significance of association for 10 GSP and GSN gene and term sets detected by CoCiter or the GO-based analysis.

ID	Type	CoCiter gene- gene analysis	CoCiter gene- term analysis	Fisher's exact test
hsa00071: Fatty acid metabolism VS. GO:0000038∼ very-long-chain fatty acid metabolic process	GSP	0	0.002	0.010020764
hsa04310: Wnt signaling pathway VS. GO:0017147∼ Wnt-protein binding	GSP	0	0	0.010598356
hsa04070: Phosphatidylinositol signaling system VS. GO:0008526∼ phosphatidylinositol transporter activity	GSP	0.004	0.003	0.011084552
hsa00252: Alanine and aspartate metabolism VS. GO:0009067∼ aspartate family amino acid biosynthetic process	GSP	0.014	0.006	0.011268153
hsa04540: Gap junction VS. GO:0005243∼ gap junction channel activity	GSP	0.002	0	0.011605198
hsa04010: MAPK signaling pathway VS. GO:0043409∼ negative regulation of MAPKKK cascade	GSP	0	0.006	0.012145396
hsa04020: Calcium signaling pathway VS. GO:0051925∼ regulation of calcium ion transport via voltage-gated calcium channel	GSP	0	0.008	0.012581597
hsa04910: Insulin signaling pathway VS. GO:0032868∼ response to insulin stimulus	GSP	0.004	0.004	0.013070018
hsa04210: Apoptosis VS. GO:0042771∼ DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GSP	0	0	0.013908051
hsa04510: Focal adhesion VS. GO:0051895∼ negative regulation of focal adhesion formation	GSP	0	0	0.014279408
hsa05030: Amyotrophic lateral sclerosis (ALS) VS. GO:0008624∼ induction of apoptosis by extracellular signals	GSP	0	0.009	0.016153439
hsa05219: Bladder cancer VS. GO:0044444∼ cytoplasmic part	GSN	0	0	0.000597928
hsa04664: Fc epsilon RI signaling pathway VS. GO:0046456∼ icosanoid biosynthetic process	GSN	0.001	0	0.001236482
hsa05040: Huntington's disease VS. GO:0030685∼ nucleolar preribosome	GSN	0	0.017	0.002211231
hsa04012: ErbB signaling pathway VS. GO:0050877∼ neurological system process	GSN	0	0	0.00252409
hsa00561: Glycerolipid metabolism VS. GO:0010033∼ response to organic substance	GSN	0.019	1	0.00258624
hsa04614: Renin-angiotensin system VS. GO:0004245∼ neprilysin activity	GSN	0	1	0.002828214
hsa04130: SNARE interactions in vesicular transport VS. GO:0006906∼ vesicle fusion	GSN	0.002	1	0.005413028
hsa00252: Alanine and aspartate metabolism VS. GO:0016885∼ ligase activity, forming carbon-carbon bonds	GSN	0	0.104	0.005649569
hsa05212: Pancreatic cancer VS. GO:0050801∼ ion homeostasis	GSN	0	0.007	0.008080875
hsa04350: TGF-beta signaling pathway VS. GO:0045687∼ positive regulation of glial cell differentiation	GSN	0	1	0.008538547

These GSP and GSN pairs are at the border of the Fisher exact test significance level p = 0.01. The full table is shown in Table S8 in File S2.