Table 3. Frequencies of HLA-DRB1-DQB1 blocks in 234 Mexican admixed individuals (468 haplotypes).
| DRB1-DQB1 block | n | H.F. | Δ′ | t | DRB1-DQB1 block | n | H.F. | Δ′ | t | ||||
| Amerindian | DRB1*08∶02 | DQB1*04∶02 | 89 | 0.1902 | 0.9723 | 12.33 | African | DRB1*10∶01 | DQB1*05∶01 | 5 | 0.0107 | 0.8211 | 2.24 |
| DRB1*04∶07 | DQB1*03∶02 | 54 | 0.1153 | 0.9518 | 8.51 | DRB1*13∶01 | DQB1*03∶03 | 4 | 0.0086 | 0.3942 | 1.96 | ||
| DRB1*14∶06 | DQB1*03∶01 | 46 | 0.0983 | 0.9717 | 7.88 | DRB1*08∶04 | DQB1*03∶01 | 2 | 0.0043 | 1.0000 | 1.55 | ||
| DRB1*16∶02 | DQB1*03∶01 | 30 | 0.0641 | 1.0000 | 6.25 | DRB1*03∶02 | DQB1*04∶02 | 1 | 0.0022 | 1.0000 | 1.05 | ||
| DRB1*14∶02 | DQB1*03∶01 | 11 | 0.0235 | 1.0000 | 3.68 | DRB1*12∶01 | DQB1*05∶01 | 1 | 0.0022 | 0.4632 | 0.93 | ||
| DRB1*04∶11 | DQB1*03∶02 | 8 | 0.0171 | 0.8526 | 2.93 | DRB1*13∶01 | DQB1*05∶01 | 1 | 0.0022 | 0.0159 | 0.18 | ||
| DRB1*04∶10 | DQB1*04∶02 | 1 | 0.0022 | 0.3706 | 0.71 | DRB1*13∶04 | DQB1*03∶01 | 1 | 0.0022 | 1.0000 | 1.10 | ||
| DRB1*04∶11 | DQB1*04∶02 | 1 | 0.0022 | −0.4595 | −0.70 | DRB1*15∶03 | DQB1*06∶02 | 1 | 0.0022 | 1.0000 | 1.00 | ||
| Total | 240 | 0.5129 | Total | 16 | 0.0346 | ||||||||
| Caucasian | DRB1*03∶01 | DQB1*02∶01 | 15 | 0.0320 | 1.0000 | 4.02 | Asian | DRB1*11∶02 | DQB1*03∶01 | 3 | 0.0064 | 0.6674 | 1.60 |
| DRB1*15∶01 | DQB1*06∶02 | 15 | 0.0320 | 0.8779 | 4.01 | DRB1*04∶04 | DQB1*04∶02 | 2 | 0.0043 | −0.6862 | −2.03 | ||
| DRB1*04∶02 | DQB1*03∶02 | 10 | 0.0214 | 1.0000 | 3.50 | DRB1*09∶01 | DQB1*03∶03 | 1 | 0.0022 | 1.0000 | 1.00 | ||
| DRB1*11∶04 | DQB1*03∶01 | 8 | 0.0171 | 1.0000 | 3.13 | DRB1*12∶01 | DQB1*03∶01 | 1 | 0.0022 | 0.3348 | 0.63 | ||
| DRB1*13∶01 | DQB1*06∶03 | 6 | 0.0128 | 1.0000 | 2.49 | DRB1*13∶01 | DQB1*06∶02 | 1 | 0.0022 | 0.0487 | 0.59 | ||
| DRB1*07∶01 | DQB1*03∶03 | 5 | 0.0107 | 0.4620 | 2.10 | DRB1*13∶02 | DQB1*05∶01 | 1 | 0.0022 | 0.0338 | 0.33 | ||
| DRB1*04∶01 | DQB1*03∶02 | 3 | 0.0064 | 1.0000 | 1.90 | DRB1*15∶01 | DQB1*05∶01 | 1 | 0.0022 | −0.1415 | −0.16 | ||
| DRB1*11∶01 | DQB1*03∶01 | 2 | 0.0043 | 0.1130 | 0.40 | ||||||||
| DRB1*04∶07 | DQB1*03∶01 | 1 | 0.0022 | −0.9268 | −3.80 | Total | 10 | 0.0217 | |||||
| DRB1*08∶03 | DQB1*03∶01 | 1 | 0.0022 | 1.0000 | −0.60 | ||||||||
| Total | 66 | 0.1411 | |||||||||||
| Caucasian shared with other populations | DRB1*04∶04 | DQB1*03∶02 | 29 | 0.0620 | 0.9144 | 5.92 | DRB1*04∶07 | DQB1*06∶04 | 1 | 0.0022 | −0.1509 | −0.17 | |
| DRB1*07∶01 | DQB1*02∶02 | 28 | 0.0598 | 1.0000 | 5.66 | DRB1*10∶01 | DQB1*05∶02 | 1 | 0.0022 | 0.3247 | 0.98 | ||
| DRB1*01∶02 | DQB1*05∶01 | 11 | 0.0235 | 1.0000 | 3.41 | DRB1*11∶02 | DQB1*03∶19 | 1 | 0.0022 | 0.2419 | 0.98 | ||
| DRB1*04∶03 | DQB1*03∶02 | 10 | 0.0214 | 1.0000 | 3.50 | DRB1*14∶06 | DQB1*04∶02 | 1 | 0.0022 | −0.8965 | −3.37 | ||
| DRB1*01∶01 | DQB1*05∶01 | 9 | 0.0192 | 1.0000 | 3.07 | DRB1*16∶01 | DQB1*05:New† | 1 | 0.0022 | 1.0000 | 1.00 | ||
| DRB1*13∶02 | DQB1*06∶04 | 9 | 0.0192 | 0.8978 | 3.07 | Total | 7 | 0.0153 | |||||
| DRB1*14∶01 | DQB1*05∶03 | 8 | 0.0171 | 1.0000 | 2.89 | ||||||||
| DRB1*15∶02 | DQB1*06∶01 | 5 | 0.0107 | 1.0000 | 2.27 | ||||||||
| DRB1*11∶01 | DQB1*03∶19 | 4 | 0.0086 | 0.7974 | 2.02 | ||||||||
| DRB1*01∶03 | DQB1*05∶01 | 3 | 0.0064 | 1.0000 | 1.75 | ||||||||
| DRB1*12∶02 | DQB1*03∶01 | 3 | 0.0064 | 1.0000 | 1.90 | ||||||||
| DRB1*13∶03 | DQB1*03∶01 | 3 | 0.0064 | 1.0000 | 1.90 | ||||||||
| DRB1*04∶05 | DQB1*03∶02 | 1 | 0.0022 | 1.0000 | 1.09 | ||||||||
| DRB1*04∶08 | DQB1*03∶01 | 1 | 0.0022 | 1.0000 | 1.10 | ||||||||
| DRB1*04∶10 | DQB1*03∶02 | 1 | 0.0022 | 0.3366 | 0.63 | ||||||||
| DRB1*08∶01 | DQB1*04∶02 | 1 | 0.0022 | 1.0000 | 1.05 | ||||||||
| DRB1*13∶05 | DQB1*03∶01 | 1 | 0.0022 | 1.0000 | 1.10 | ||||||||
| DRB1*15∶01 | DQB1*05∶02 | 1 | 0.0022 | 0.3081 | 0.93 | ||||||||
| DRB1*16∶01 | DQB1*05∶02 | 1 | 0.0022 | 0.4968 | 1.00 | ||||||||
| Total | 129 | 0.2761 | |||||||||||
Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider t value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).† Similar to DQB1*05∶02 with a silent mutation at codon 133 cgg>cga.