Figure 5. Antiretroviral activity of ciclopirox in slow-onset infection of primary cells.

Uninfected PBMCs from a single-donor were infected with isolate #990,135. Cultures were left untreated (open squares) or either CPX (red triangles) or Agent P2 (green circles) was added at 48 hr after plating/inoculation to 30 µM (small symbols) or 60 µM (large symbols). HIV-1 protein (p24; A) and copy number (HIV-1 RNA; B) were assayed at 24-hr intervals.