Table 1. Association with risk of follicular cell-derived thyroid cancer for 9 candidate variants in the discovery and replication stages.

SNP (alleles)a	Gene	Location, function	Group of cases	Best fitting model	Discoveryd			Replicatione
					MAF in cont; cases	OR (95% CI)b	P c	MAF in cont; cases	OR (95% CI)b	P c
rs16973034 (A/G)	PRKAR1A	intronic, tagSNP	PTC	dominant	0.153; 0.108	0.63 (0.47–0.84)	1.8×10−3	0.138; 0.133	1.00 (0.79–1.26)	0.984
rs2703488 (T/C)	KIT	intronic, tagSNP	PTC	dominant	0.488; 0.551	1.43 (1.07–1.91)	1.5×10−2	0.476; 0.472	0.93 (0.75–1.16)	0.522
rs4939827 (T/C)	SMAD7	intronic, tagSNP	PTC	recessive	0.461; 0.416	0.68 (0.50–0.94)	1.9×10−2	0.438; 0.478	1.32 (1.03–1.68)	0.027
rs2066807 (G/C)	STAT2	exonic, p.Met594Ile	PTC	dominant	0.033; 0.054	1.69 (1.06–2.69)	2.6×10−2	0.040; 0.039	0.98 (0.68–1.42)	0.928
rs2284734 (A/G)	TSHR	intronic, tagSNP	cPTC	recessive	0.290; 0.388	2.64 (1.69–4.13)	1.8×10−5	0.304; 0.317	1.42 (0.99–2.03)	0.058
rs1053266 (G/T)	CCDC6	exonic, p.Pro470Thr	cPTC	recessive	0.494; 0.543	1.37 (0.96–1.97)	8.7×10−2	0.471; 0.502	1.24 (0.96–1.60)	0.103
rs2687834 (G/T)	TG	intronic, tagSNP	fvPTC	recessive	0.447; 0.565	2.28 (1.50–3.46)	1.1×10−4	0.491; 0.477	0.74 (0.46–1.17)	0.195
rs6179 (G/A)	GHR	exonic, ESE	FTC	dominant	0.356; 0.232	0.46 (0.27–0.80)	5.4×10−3	0.299; 0.286	0.87 (0.55–1.37)	0.543
rs13099828 (C/G)	PPARG	intronic, tagSNP	fvPTC+FTC	dominant	0.186; 0.256	1.71 (1.22–2.38)	1.6×10−3	0.168; 0.189	1.01 (0.71–1.46)	0.936

Abbreviations: MAF = minor allele frequency; OR = odds ratio; CI = confidence interval; ESE = Exonic Splicing Enhancers; PTC = Papillary Thyroid Carcinoma; cPTC = classic PTC; fvPTC = follicular variant of PTC; FTC = Follicular Thyroid Carcinoma. The table is sorted by disease subtype and, within each group, by P-value.

^aMajor/minor allele (in controls);

^bOR and CI were obtained using homozygotes for the most frequent allele in controls as the reference group;

^c P-values are derived from Wald statistics;

^dResults adjusted for age and gender;

^eResults adjusted for age, gender and country.