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. 2013 Sep 23;8(9):e74765. doi: 10.1371/journal.pone.0074765

Table 2. Table 2. Gene-gene interaction results for susceptibility to Papillary Thyroid Carcinoma overall.

SNP1 GENE SNP2 GENE MDR SH MECPM MSH MBMDR*
rs721992 CCDC6 rs6554198 KIT <0.0001
rs11985450 ChGn rs3021526 FOXE1 0.0637
rs2395911 SLC26A4 rs1799977 MLH1 0.0002
rs16945753 MED13 rs2979033 TG 0.0045
rs8069645 STAT3 rs2979040 TG 0.0035
rs10119760 FOXE1 rs2958681 TG 0.0190
rs3111800 KIT rs4607021 ITGB2 0.0010
rs10119760 FOXE1 rs15866 STK17A 0.0084
rs6556301 FGFR4 rs6948512 SHH 0.0085
rs2958681 TG rs7350420 NCOA4 0.0298
rs1044217 STK17A rs2958681 TG 0.0114
rs12667481 SLC26A4 rs6180 GHR NA
rs440555 ITGB2 rs6180 GHR 0.0332
rs16945753 MED13 rs17202345 CCDC6 0.0735
rs1648305 DUOX1 rs3098233 CTHRC1 0.0854
rs2703488 KIT rs6018257 SRC 0.0785
rs17705719 TG rs15997 RAF1 0.1085

SH- SNPHarvester; MSH- MegaSNPHunter; light grey shading indicates interactions selected by each of the algorithms; dark grey shading indicates the interaction fulfilling the established cutoff (SNP pair selected by at least three methods);

*

associated P-value; NA- not available (all genotypes combinations classified as neutral).