Table 2. Table 2. Gene-gene interaction results for susceptibility to Papillary Thyroid Carcinoma overall.
SNP1 | GENE | SNP2 | GENE | MDR | SH | MECPM | MSH | MBMDR* |
rs721992 | CCDC6 | rs6554198 | KIT | <0.0001 | ||||
rs11985450 | ChGn | rs3021526 | FOXE1 | 0.0637 | ||||
rs2395911 | SLC26A4 | rs1799977 | MLH1 | 0.0002 | ||||
rs16945753 | MED13 | rs2979033 | TG | 0.0045 | ||||
rs8069645 | STAT3 | rs2979040 | TG | 0.0035 | ||||
rs10119760 | FOXE1 | rs2958681 | TG | 0.0190 | ||||
rs3111800 | KIT | rs4607021 | ITGB2 | 0.0010 | ||||
rs10119760 | FOXE1 | rs15866 | STK17A | 0.0084 | ||||
rs6556301 | FGFR4 | rs6948512 | SHH | 0.0085 | ||||
rs2958681 | TG | rs7350420 | NCOA4 | 0.0298 | ||||
rs1044217 | STK17A | rs2958681 | TG | 0.0114 | ||||
rs12667481 | SLC26A4 | rs6180 | GHR | NA | ||||
rs440555 | ITGB2 | rs6180 | GHR | 0.0332 | ||||
rs16945753 | MED13 | rs17202345 | CCDC6 | 0.0735 | ||||
rs1648305 | DUOX1 | rs3098233 | CTHRC1 | 0.0854 | ||||
rs2703488 | KIT | rs6018257 | SRC | 0.0785 | ||||
rs17705719 | TG | rs15997 | RAF1 | 0.1085 |
SH- SNPHarvester; MSH- MegaSNPHunter; light grey shading indicates interactions selected by each of the algorithms; dark grey shading indicates the interaction fulfilling the established cutoff (SNP pair selected by at least three methods);
associated P-value; NA- not available (all genotypes combinations classified as neutral).