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. 2013 Sep 23;8(9):e74029. doi: 10.1371/journal.pone.0074029

Figure 2. Secretoneurin gene therapy improves blood flow monitored in vivo by LDPI in diabetic mice.

Figure 2

(A) Time course of hind limb blood flow measured by LDPI is expressed as ischemic-to-control leg ratio. Treatment with p-SN significantly improved perfusion 7, 14 and 28 days after induction of ischemia compared to p-CTR: #, p<0.05. (B) Representative pictures of the ischemic (left) and non ischemic (right) hind limbs on day 28 after ischemia induction. In color-coded images treatment with p-SN improves perfusion where red indicates normal perfusion and blue indicates a marked reduction in blood flow in the ischemic hind limb.