Table 2.
Study variables by cohort and hsCRP group.
| Mean (SD) or Geometric Mean [1st quartile, 3rd quartile] |
||||||||
|---|---|---|---|---|---|---|---|---|
| Adult | Adolescent | |||||||
| Low (hsCRP ≤ 1) | Middle (1 < hsCRP ≤ 3) | High (hsCRP > 3) | p† | Low (hsCRP ≤ 1) | Middle (1 < hsCRP ≤ 3) | High (hsCRP > 3) | p† | |
| Variable | (N = 159) | (N = 160) | (N = 165) | (N = 165) | (N = 71) | (N = 46) | ||
| hsCRP (mg/dl)‡ | 0.49 [0.30, 0.90] | 1.74 [1.40, 2.20] | 5.17 [3.90, 6.50] | 0.32 [0.20, 0.60] | 1.79 [1.40, 2.30] | 5.19 [3.80, 6.90] | ||
| Waist Circumference (cm)‡ | 87.98 [80.00, 96.00] | 98.16 [89.00, 109.00] | 104.93 [92.99, 117.50] | <.001 | 79.58 [70.10, 87.50] | 94.39 [87.00, 107.50] | 104.15 [93.00, 119.40] | <.001 |
| BMI (kg/m2)‡ | 26.87 [23.06, 30.34] | 30.72 [26.78, 35.23] | 34.68 [28.80, 40.78] | <.001 | 25.24 [21.10, 29.17] | 31.84 [27.83, 36.28] | 36.37 [32.69, 43.06] | <.001 |
| SBP (mmHg)[‡ | 118.56 [109.0, 128.0] | 122.86 [112.00, 133.50] | 120.60 [110.0, 130.0] | 0.089 | 111.98 [105.0, 119.3] | 114.16 [106.33, 122.67] | 114.85 [106.7, 121.3] | 0.211 |
| DBP (mmHg)‡ | 73.30 [64.00, 82.00] | 77.17 [70.00, 84.00] | 73.21 [66.00, 80.00] | 0.005 | 62.25 [57.67, 68.00] | 62.45 [57.67, 67.00] | 63.20 [58.67, 67.00] | 0.794 |
| HDL (mg/dl) | 50.51 (14.59) | 48.68 (15.39) | 44.78 (13.75) | 0.003 | 55.16 (12.35) | 48.86 (12.59) | 49.37 (11.83) | 0.001 |
| LDL (mg/dl) | 104.17 (29.48) | 110.73 (26.89) | 110.52 (30.69) | 0.114 | 85.94 (23.80) | 91.15 (27.77) | 94.39 (33.44) | 0.218 |
| Total Cholesterol (mg/dl) | 169.43 (31.67) | 176.30 (29.55) | 172.56 (35.62) | 0.200 | 153.93 (27.67) | 155.23 (31.27) | 159.11 (35.31) | 0.713 |
| Triglycerides (mg/dl)‡ | 65.74 [48.00, 87.00] | 76.86 [52.00, 106.50] | 74.81 [54.00, 97.00] | 0.016 | 57.46 [44.00, 71.00] | 67.00 [49.00, 88.00] | 70.23 [54.00, 97.00] | 0.003 |
| Fasting Glucose (mg/dl) | 99.45 (11.81) | 103.34 (15.60) | 108.04 (25.29) | <.001 | 95.98 (8.69) | 96.54 (7.80) | 100.80 (17.14) | 0.257 |
| Composite ISI‡ | 7.61 [5.11, 11.98] | 6.30 [3.77, 11.32] | 4.98 [2.88, 8.86] | <.001 | 5.78 [3.91, 8.49] | 4.15 [2.64, 7.02] | 3.13 [2.10, 5.11] | <.001 |
| HOMA‡ | 1.22 [0.76, 1.70] | 1.50 [0.83, 2.45] | 2.01 [1.02, 3.67] | <.001 | 1.46 [0.94, 2.12] | 2.33 [1.32, 3.63] | 3.13 [1.97, 5.28] | <.001 |
| UAE (mg/gmcreat)‡ | 4.03 [1.49,11.11] | 5.45 [1.96,15.61] | 5.76 [2.25,14.28] | 0.102 | 2.61 [1.10, 6.49] | 2.22 [1.07, 3.51] | 2.59 [0.82, 7.19] | 0.680 |
| Adiponectin (μg/ml)‡ | 5.63 [3.50, 9.10] | 4.51 [3.05, 7.35] | 4.34 [2.80, 6.90] | 0.002 | 6.41 [4.30,10.10] | 4.75 [3.50, 7.10] | 4.18 [2.50, 6.00] | <.001 |
| IL6 (pg/ml)‡ | 1.57 [1.00, 2.40] | 2.12 [1.50, 3.10] | 3.92 [2.30, 6.70] | <.001 | 2.58 [1.90, 3.60] | 3.18 [2.10, 4.20] | 4.26 [3.30, 5.20] | <.001 |
| PAI1 (ng/ml) | 60.32 (29.54) | 71.62 (32.59) | 75.71 (31.72) | <.001 | 50.65 (23.93) | 69.61 (25.88) | 79.21 (25.91) | <.001 |
| TNFα (pg/ml)‡ | 6.23 [5.20, 9.40] | 6.73 [5.70, 9.40] | 7.50 [6.00, 9.50] | 0.043 | 8.49 [7.20, 9.60] | 8.26 [6.80, 9.90] | 8.15 [6.50,10.00] | 0.786 |
| TNFα Receptor (pg/ml)‡ | 0.80 [0.60, 1.00] | 0.82 [0.60, 1.00] | 0.94 [0.70, 1.20] | 0.004 | 0.88 [0.70, 1.10] | 0.96 [0.70, 1.20] | 1.07 [0.90, 1.30] | 0.003 |
†
Fishers exact test (categorical) or ANOVA F-test (continuous); adjustments made for multiple testing
‡
Data natural log transformed: geometric means with [first quartile, third quartile] presented. The SI conversion factor for HDL, LDL, and Total Cholesterol is 0.0259. The SI conversion factor for glucose is 0.0555. The SI conversion factor for PAI1 is 19.231. The SI conversion factor (approximate) for Il-6 is 0.131. The SI conversion factor (approximate) for TNFα is 0.086