Table 1.

Representative metalloproteins that are therapeutic targets.

Protein	Cofactor	Indication
Adamalysin	Zn(II)	Cancer
Angiotensin Converting Enzyme*	Zn(II)	Hypertension
Anthrax Lethal Factor	Zn(II)	Pathogen (Toxin)
Botulinum Neurotoxin	Zn(II)	Pathogen (Toxin)
Carbonic Anhydrase*	Zn(II)	Glaucoma
Farnesyltransferase	Zn(II)	Cancer
Histone Deacetlyase*	Zn(II)	Cancer
Matrix Metalloprotease*	Zn(II)	Cancer, Inflammation
Metallo-β-Lactamase	Zn(II)	Bacterial Infection
Neprilysin	Zn(II)	Hypertension
TNF-α Converting Enzyme	Zn(II)	Cancer
Lipoxygenase*	Fe(II)	Asthma
HIV Integrase*	Mg(ll)	Viral Infection

^*FDA-approved inhibitors exist for these metalloproteins