Figure 4. Dominance of Raf-1 in promoting proliferation and drug resistance. Growth was measured over a period of 4 d in the presence of no drugs (A–C), 25 nM doxorubicin (D–F) or 10 nM paclitaxel (G–I). Symbols: solid squares (■) = no supplement, solid downward triangles (▼) = 100 nM Test, solid upward triangles (▲) = 500 nM 4HT, solid diamonds (◆) = 500 nM 4HT + 100 nM Test. Each data point is the average of 8 replicates.