Table 1. Differences in chemotherapeutic drug IC50s in non-selected and doxorubicin-selected FL/ΔAkt-1:ER*(Myr+) + ΔRaf-1:AR cells1.
Cell line→ | Non-selected | Doxorubicin-selected | Fold difference |
---|---|---|---|
Drug↓ |
|
|
|
Doxorubicin |
25 ± 6 nM |
65 ± 11 nM |
2.6X |
Daunorubicin |
9 ± 3 nM |
18 ± 5 nM |
2.0X |
Paclitaxel |
3 ± 0.8 nM |
13 ± 2 nM |
4.3X |
Cisplatin |
80,000 ± 9,000 |
90,000 ± 11,000 nM |
1.1X |
5-Flurouracil | 1,000 ± 200 nM | 1,200 ± 100 nM | 1.2X |
1 Determined by plating 2,500 cells/well in 96 well plates in 500 nM 4HT + 100 nM as described in materials and methods.