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. 2010 May 1;9(9):1781–1791. doi: 10.4161/cc.9.9.11483

Table 1. Differences in chemotherapeutic drug IC50s in non-selected and doxorubicin-selected FL/ΔAkt-1:ER*(Myr+) + ΔRaf-1:AR cells1.

Cell line→ Non-selected Doxorubicin-selected Fold difference
Drug
 
 
 
Doxorubicin
25 ± 6 nM
65 ± 11 nM
2.6X
Daunorubicin
9 ± 3 nM
18 ± 5 nM
2.0X
Paclitaxel
3 ± 0.8 nM
13 ± 2 nM
4.3X
Cisplatin
80,000 ± 9,000
90,000 ± 11,000 nM
1.1X
5-Flurouracil 1,000 ± 200 nM 1,200 ± 100 nM 1.2X

1 Determined by plating 2,500 cells/well in 96 well plates in 500 nM 4HT + 100 nM as described in materials and methods.