Figure 1. Comparison of the domain architecture between the MORC family (A) and the well-characterized four classes of chromatin remodeling complexes (B). (A) Members of the MORC family contain a conserved GHKL-type ATPase domain at their N-terminus, a PHD-X/ZF-CW domain in their midst and varied coiled-coil domains. In addition, MORC2 protein contains a chromo-like domain at its carboxy-terminus. (B) The ATPase subunits of the four classes of chromatin remodeling complexes including SWI/SNF (SWItch/sucrose non-fermentable), ISWI (imitation switch), CHD (chromodomain, helicase, DNA binding) and INO80 (inositol requiring 80) contain a common Snf2-like ATPase domain and other functional domains as indicated.^29,30