Table 3. Functions of MORCs in transcription and DNA damage response.
| MORCs | Functions | References | |
|---|---|---|---|
| Transcription |
MORC2 |
Transcription repression of CAIX gene |
16
|
| |
MORC3 |
SUMO-mediated transcriptional repression |
85
|
| |
SMCHD1 |
X inactivation and CpG island hypermethylation |
22
,
86
|
| |
DMS3 (Arabidopsis) |
RNA-mediated DNA methylation |
36
,
87
|
| |
AtMORC1 (CRT1) |
Heterochromatin condensation and gene silencing |
26
|
| |
AtMORC6 (DMS11) |
Heterochromatin condensation and gene silencing |
26
|
| |
|
RNA-directed DNA methylation |
36
|
| DDR |
MORC2 |
Chromatin remodeling and DNA repair |
4
|
| |
AtMORC1 (CRT1) |
Tolerance to DNA-damage agent mitomycin C |
88
|
| GMI1 (Arabidopsis) | Repair of DNA double-strand breaks | 35 |
CAIX, carbonic anhydrase IX; DMS, defective in meristem silencing; GMI1, gamma-irradiation and mitomycin C induced 1.