Fig. 3.

Subdivision of the neural plate in discreet gene expression domains. a At presomitic/early somite stages, in situ hybridization for Hesx1 (red) and Pax2 (purple), marking the anterior forebrain and posterior forebrain/midbrain precursors, respectively. b The anterior forebrain primordium express Hesx1 (red), and Pax3 (purple), delineates a posterior-lateral domain that gives rise to neural crest cells in an older embryo. Note that these domains do not overlap (adapted with permission from Disease Models and Mechanisms (Sajedi et al. (2008), Disease Models and Mechanisms 1 (4–5), 241–254)