Fig. 2.

Time course of percentage change in heart rate (mean ± standard deviation). Pre 1 measurement of heart rate 3 min (sinus tachycardia), 1 min (other than sinus tachycardia), or 1 min (tachycardia with abnormal ST segment) before initiation of infusion, Pre 2 measurement of heart rate conducted immediately before initiation of infusion, C sum of the result immediately after completion of infusion plus the results at discontinuation of infusion. Refer to Table 1 for treatment group definitions. *Dunnett test; significance was defined as p < 0.05 (two-tailed)