Table 3.

Changes in electrocardiogram parameters

	Treatment group									Dunnett test
	PP group			LM group			MH group
	n	Value	Change	n	Value	Change	n	Value	Change	PP vs. LM	PP vs. MH
RR interval
Pre	50	0.442 ± 0.043		50	0.456 ± 0.040		51	0.458 ± 0.033
Post	48	0.456 ± 0.052	0.013 ± 0.039	48	0.598 ± 0.059	0.142 ± 0.057	50	0.575 ± 0.086	0.116 ± 0.073	p = 0.0001	p = 0.0001
PQ interval
Pre	21	0.144 ± 0.024		28	0.141 ± 0.016		28	0.146 ± 0.020
Post	24	0.148 ± 0.019	0.002 ± 0.012	30	0.155 ± 0.019	0.014 ± 0.017	32	0.163 ± 0.023	0.018 ± 0.017	p = 0.0160	p = 0.0015
QRS duration
Pre	46	0.083 ± 0.013		47	0.083 ± 0.012		47	0.083 ± 0.010
Post	46	0.082 ± 0.012	−0.001 ± 0.005	45	0.084 ± 0.013	0.000 ± 0.003	47	0.084 ± 0.010	0.000 ± 0.003	p = 0.0483	p = 0.0483
QT interval
Pre	30	0.322 ± 0.042		31	0.313 ± 0.039		38	0.306 ± 0.035
Post	32	0.320 ± 0.035	0.001 ± 0.017	32	0.360 ± 0.051	0.041 ± 0.037	40	0.341 ± 0.043	0.033 ± 0.029	p = 0.0001	p = 0.0001
ST segment
Pre	33	0.038 ± 0.057		37	0.039 ± 0.041		39	0.064 ± 0.073
Post	35	0.039 ± 0.057	−0.004 ± 0.023	37	0.041 ± 0.047	−0.001 ± 0.050	39	0.049 ± 0.056	−0.008 ± 0.042	p = 0.9418	p = 0.8979
QTc
Pre	30	0.478 ± 0.063		31	0.457 ± 0.053		38	0.451 ± 0.049
Post	32	0.467 ± 0.054	-0.004 ± 0.031	32	0.463 ± 0.056	0.001 ± 0.048	40	0.449 ± 0.049	−0.003 ± 0.034	p = 0.8529	p = 0.9933

Refer to Table 1 for treatment group definitions