Table 2.
Pharmacokinetic parameters for edoxaban
| Variable | Quinidine 300 mg | Digoxin 0.25 mg | Amiodarone 400 mg | |||
|---|---|---|---|---|---|---|
| Edoxaban | Edoxaban + Quinidine | Edoxaban | Edoxaban + Digoxin | Edoxaban | Edoxaban + Amiodarone | |
| Cmax (ng/mL) | 223.4 (75.0) | 390.4 (93.4) | 250.0 (75.7) | 296.2 (105.6) | 251.3 (100.8) | 401.6 (109.3) |
| C24 (ng/mL) | 11.0 (4.4) | 12.3 (4.3) | 24.5 | 22.2 | 11.3 (5.5) | 8.4 (3.2) |
| tmax (h) | 1.48 (0.50–6.00) | 1.50 (0.48–2.50) | 1.00 (0.98–2.00) | 1.50 (0.98–2.00) | 1.25 (0.50–3.00) | 1.50 (0.98–4.00) |
| AUC0–24 (ng·h/mL) | 1449.2 (328.6) | 2485.3 (402.5) | – | – | – | – |
| AUClast (ng·h/mL) | 1443.4 (329.7) | 2484.4 (402.4) | – | – | 1718.1 (351.6) | 2415.6 (419.0) |
| AUC0–inf (ng·h/mL) | 1576.8 (322.7) | 2575.3 (414.1) | – | – | 1743.1 (354.2) | 2431.5 (418.7) |
| AUC0–τ (ng·h/mL) | – | – | 1963.1 (353.8) | 2167.0 (478.2) | – | – |
| t1/2 (h) | 6.43a (1.59) | 4.97a (0.62) | 9.83a (3.98) | 8.35a (4.23) | 12.25b (5.03) | 10.81b (4.84) |
All values are mean (SD) except tmax, which is median (minimum–maximum)
AUC area under the curve, C max maximum plasma concentration, C 24 plasma concentration at 24 h postdose, SD standard deviation, t max time to Cmax, t 1/2 terminal half-life
aSerial measurements to 24 h
bSerial measurements to 72 h