Table 3.
Pharmacokinetic parameters for edoxaban
| Variable | Verapamil 240 mg SR | Atorvastatin 80 mg | Dronedarone 400 mg | |||
|---|---|---|---|---|---|---|
| Edoxaban | Edoxaban + Verapamil | Edoxaban | Edoxaban + Atorvastatin | Edoxaban | Edoxaban + Dronedarone | |
| Cmax (ng/mL) | 226.1 (104.9) | 319.7 (95.7) | 282.2 (88.6) | 244.2 (87.3) | 295.6 (83.6) | 422.4 (70.4) |
| C24 (ng/mL) | 11.0 (4.0) | 14.2 (7.1) | 12.6 (5.1) | 13.6 (4.8) | 5.9 (2.0) | 15.2 (6.0) |
| tmax (h) | 1.48 (0.52–2.98) | 1.00 (0.48–2.98) | 1.02 (0.48–5.98) | 1.50 (0.48–3.00) | 1.98 (0.50–4.03) | 2.03 (1.00–4.00) |
| AUC0–24 (ng·h/mL) | 1438 (416.7) | 2105 (372.3) | – | – | – | – |
| AUClast (ng·h/mL) | – | – | – | – | 1659.5 (310.8) | 3007.4 (604.5) |
| AUC0–inf (ng·h/mL) | – | – | 1965.5 (420.9) | 1983.0 (351.4) | 1682.5 (313.8) | 3070.7 (565.5) |
| t1/2 (h) | 7.43a (2.33) | 6.79a (1.99) | 12.02b (3.46) | 12.77b (3.12) | 10.2b (6.78) | 12.8b (6.23) |
All values are mean (SD) except tmax, which is median (minimum–maximum)
AUC area under the curve, C max maximum plasma concentration, C 24 plasma concentration at 24 h postdose, SD standard deviation, t max time to Cmax, t 1/2 terminal half-life
aSerial measurements to 24 h
bSerial measurements to 72 h