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. 2013 Sep 24;7:163. doi: 10.3389/fncel.2013.00163

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Copyright © Knauss, Bian and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Target protectors block miR-19a repression of Pten in the developing mouse cortex. (A–D) Electroporation of the 60 nt target protector at E13.5 for analysis at E14.5 significantly decreased the number of BrdU-incorporating or Ki67⁺ proliferative cells colabeled with GFP in the cortex. Ectopic expression of full length Pten containing the 3′UTR (Pten-FL-3′UTR) showed a similar effect, while co-electroporation of Pten-FL-3′UTR and miR-19a ablated this effect. Data are presented as mean ± SD; n ≥ 3 for all electroporations; p values in relation to control (***p < 0.001). Scale bar: 50 μm.